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  2. Volume 8, Issue 3
  3. Author

Online ISSN: 2515-8260

Volume8, Issue3

Rhematoid Arthrits Effects Associated with Hypovitaminosis K

    Amal Bakry Ahmed MD, HaidyZedan MD, Shimaa Mostafa MD, NesmaSmedaSeliman

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 4288-4298

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Abstract

Background:Rheumatoid arthritis (RA) is a progressive inflammatory autoimmune disease with
articular and systemic effects. Its exact cause is unknown, but genetic and environmental
factors are contributory. Although some patients have mild self-limited disease, many
experience joint destruction, severe physical disability and multiple co-morbidities. T cells, B
cells and the interaction of pro-inflammatory cytokines play key roles in the pathophysiology of
RA.In addition to the effect of vitamin K on blood coagulation, several studies have indicated
the important role of vitamin K in bone metabolism and bone protection. Vitamin K functions as
a coenzyme for vitamin K-dependent carboxylase, an enzyme required for the synthesis of
proteins involved in hemostasis (blood clotting) and bone metabolism.Matrix Gla-protein, a
vitamin K-dependent protein present in vascular smooth muscle, bone, and cartilage, is the
focus of considerable scientific research because it might help reduce abnormal calcification.
Osteocalcin is another vitamin K-dependent protein that is present in bone and may be involved
in bone mineralization or turnover. There is evidence of a correlation between low serum levels
of vitamin k and a high incidence of femoral neck and vertebral fractures
Keywords:
    Rheumatoid arthritis (RA) Vitamin K Osteoporotic Changes
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(2021). Rhematoid Arthrits Effects Associated with Hypovitaminosis K. European Journal of Molecular & Clinical Medicine, 8(3), 4288-4298.
Amal Bakry Ahmed MD, HaidyZedan MD, Shimaa Mostafa MD, NesmaSmedaSeliman. "Rhematoid Arthrits Effects Associated with Hypovitaminosis K". European Journal of Molecular & Clinical Medicine, 8, 3, 2021, 4288-4298.
(2021). 'Rhematoid Arthrits Effects Associated with Hypovitaminosis K', European Journal of Molecular & Clinical Medicine, 8(3), pp. 4288-4298.
Rhematoid Arthrits Effects Associated with Hypovitaminosis K. European Journal of Molecular & Clinical Medicine, 2021; 8(3): 4288-4298.
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