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  2. Clinical and demographic features of SARS-COV-2 variants of concern (VOC): B.1.1.7 and B.1.617.2 At a tertiary care hospital in Southern Rajasthan

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Clinical and demographic features of SARS-COV-2 variants of concern (VOC): B.1.1.7 and B.1.617.2 At a tertiary care hospital in Southern Rajasthan

    Author

    • Dr. Neha Agrawal, Dr. Anshu Sharma, Dr. Sushil Kumar Sahu, Dr. Shubhangi Sharma, Dr. Lakhan Poswal
,

Document Type : Research Article

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Abstract

Introduction: As the global severe acute respiratory syndrome corona virus 2 (SARS-CoV-
2) pandemic expands, genomic epidemiology and whole genome sequencing are being
constantly used to investigate its transmissions and evolution.
Aims and Objectives: To ensure that best use is made of the whole genome sequencing
programmes for SARS-CoV-2 results, in improving public health. Analyze and establish a
correlation of demographic features and vaccination status with clinical outcome of
VOC’s.
Material and Method: 478 samples (December 15, 2020- June 15, 2021) were shortlisted as
per state government policy of sample selection criteria for genome sequencing, packed in
triple layer according to standard transportation protocol and sent to the National Public
Health Laboratory (NPHL) for whole genome sequencing.. The data collected by us were
analyzed and correlated with the results of whole genome sequencing, shared by the NPHL
to enhance public health impact of the variant identified.
Observation and Results: In our study we found 92% of B.1.617.2 (Delta) variants and 8%
of B.1.1.7 (Alpha) variant. We found significantly high mortality (25%) in age group > 60
years compared to other age group (20-40years, 40-60years) with Delta variant (p value <
.05). We also found that Delta variant is significantly more transmissible (p value < .05)
than Alpha variant. Mortality was significantly higher among unvaccinated patients
having co-morbid conditions rather than vaccinated patients having co-morbid conditions
with delta variant (p value <0.05).
Conclusion: B.1.617.2 (Delta) variant has emerged as a common VOC among SARS-COV-
2 patients in southern Rajasthan. Vaccination has a very high level of protective role in
decreasing mortality, especially old age patients with associated co-morbidities among
Delta variant.

Keywords

  • SARS-CoV-2
  • variant of concern
  • whole genome sequencing
  • pre-existing medical condition
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European Journal of Molecular & Clinical Medicine
Volume 8, Issue 4
July 2021
Page 702-708
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  • Article View: 253
  • PDF Download: 279

APA

Poswal, D. N. A. D. A. S. D. S. K. S. D. S. S. D. L. (2021). Clinical and demographic features of SARS-COV-2 variants of concern (VOC): B.1.1.7 and B.1.617.2 At a tertiary care hospital in Southern Rajasthan. European Journal of Molecular & Clinical Medicine, 8(4), 702-708.

MLA

Dr. Neha Agrawal, Dr. Anshu Sharma, Dr. Sushil Kumar Sahu, Dr. Shubhangi Sharma, Dr. Lakhan Poswal. "Clinical and demographic features of SARS-COV-2 variants of concern (VOC): B.1.1.7 and B.1.617.2 At a tertiary care hospital in Southern Rajasthan". European Journal of Molecular & Clinical Medicine, 8, 4, 2021, 702-708.

HARVARD

Poswal, D. N. A. D. A. S. D. S. K. S. D. S. S. D. L. (2021). 'Clinical and demographic features of SARS-COV-2 variants of concern (VOC): B.1.1.7 and B.1.617.2 At a tertiary care hospital in Southern Rajasthan', European Journal of Molecular & Clinical Medicine, 8(4), pp. 702-708.

VANCOUVER

Poswal, D. N. A. D. A. S. D. S. K. S. D. S. S. D. L. Clinical and demographic features of SARS-COV-2 variants of concern (VOC): B.1.1.7 and B.1.617.2 At a tertiary care hospital in Southern Rajasthan. European Journal of Molecular & Clinical Medicine, 2021; 8(4): 702-708.

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