REVIEW ARTICLE: INDOLE 3 CARBINOL A NOVEL APPROACH TO ANTICANCEROUS DRUG
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 4, Pages 745-750
AbstractA diet rich in cruciferous vegetables such as cauliflower, broccoli, and cabbage has long been
considered healthy, and various epidemiological studies suggest that the consumption of
cruciferous vegetables contributes to a cancer-protecting diet. While these vegetables contain
a vast array of phyto chemicals, the mechanism by which these vegetables counteract cancer
is still largely unresolved. Numerous in situ studies have implicated indole-3-carbinol, a
breakdown product of the glucosinolate indole-3-ylmethylglucosinolate, as one of the phyto
chemicals with anti-cancer properties. Indole-3-carbinol influences a range of cellular
processes, but the mechanisms by which it acts on cancer cells are slowly being revealed.
Recent studies on the role of indole-3-carbinol in Arabidopsis opens the door for crosskingdom
comparisons that can help in understanding the roles of this important
phytohormone in both plant biology and combatting cancer.
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