European Journal of Molecular & Clinical Medicine

Abstract

The fruit of Carica papaya Linn (Caricaceae) used in traditional medicine for the
treatment of urinary stones. The present study was undertaken to evaluate
theantiurolithatic effects of the aqueous and alcoholic extracts of the fruit of C. Papaya on
ethylene glycol (EG) induced urolithiatic rats. EG administration resultedin hyperoxaluria
as well as increased renal excretion of calcium and phosphate. Treatment with aqueous
and alcoholic extracts of C. papaya fruit significantlyreduced the elevated urinary oxalate,
showing a regulatory action on endogenous oxalate synthesis. The increased deposition of
stone forming constituents in thekidneys of calculogenic rats was also significantly lowered
by curative and preventive treatment using aqueous and alcoholic extracts of the fruits of
C. papaya. The results indicate that the fruit of C. papaya is endowed with antiurolithiatic
activity and scientifically valid the traditional use of the fruit of C. Papaya in the treatment
of urinary calculi.