SYNTHESIS AND ANTIDIABETIC EVALUATION OF SOME 2-SUBSTITUTED BENZOTHIAZOLE DERIVATIVES
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 1, Pages 2343-2350
AbstractA series of 2-substituted benzothiazole derivatives (3a-3j) were synthesized using appropriate synthetic route. Synthesized derivatives were confirmed by IR, 1HNMR and Mass spectrometry. All derivatives were screened for antidiabetic activity using alloxan induced method. Estimation of glucose, cholesterol and triglyceride levels were carried out. It was found that Compounds 3d exhibited significant antidiabetic activity. 3f, 3b and 3a possess a moderate antidiabetic activity.
KEYWORDS: Antidiabetic, Benzothiazole, Chloroacetanilide, Cholesterol, Glucose, Oral Hypoglycaemic, Triglyceride.
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