Ameliorative Effect of Emblica Officinalis and Zingiber Officinalis as Antioxidant on Arsenic-Lead Toxicity Induced Oxidative Changes on Brain and Testis
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 9, Pages 3940-3950
AbstractAim: This study was aimed to assess the protecting impact of Emblica officinalis (E.officinalis) and monocot genus officinalae (Z.officinalae) leaf extract on reactive element species, inhibitor potential changes in arsenic and lead- evoked toxicity in male rats. Experimental Design: Adult male Wistar rats were used and divided as Group I: Control; Group II: lead and sodium arsenite together were administered through gastric intubation during 14 consecutive days Group III to Group IX: arsenic and lead induced rats treated with ethanolic extract of Emblica officinalis, Z.officinalae orally for 45 days with different concentrations). At the end of the treatment, control and experimental animals were subjected to oxidative stress markers such as H2O2, *OH, and lipid peroxidation (LPO), antioxidant enzymes of Brain and Testis.
Results: arsenic and lead evoked rats showed a major increase within the levels of reactive element species (H2O2, OH* and LPO) with concomitant alterations within the Brain and gonad tissues. Conversely enzymic and non-enzymic inhibitor levels were found to be belittled. However, Associate in Nursing oral effective dose of E.officinalis and Z.officinalae (120 + one hundred twenty mg/kg body weight/ day multiplied the inhibitor enzymes and retrieved the altered levels of ROS and LPO that were evoked by asenic and lead.
Conclusion: it's over from these findings that E.officinalis and Z.officinalae leaf extract exhibits neuroprotective and recovers gonad harm through the restoration of reactive element species and inhibitor enzymes within the brain and gonad tissue of arsenic and lead-induced neurotoxicity and gonad toxicity in rats. Hence, E.officinalis and Z.officinalae leaf extract could also be one amongst the therapeutic choices for the treatment of metal toxicity- evoked brain and gonad diseases.
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