A Case Control Study to Assess the Pregnancy-Induced Hypertension and its Association with Elevated Homocysteine (Hcy) Levels
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 4, Pages 1384-1389
AbstractAim: To study the hyperhomocysteinemialevels in pregnancy induced hypertension. Methods: A Case control study was conducted in the Department of Obstetrics and Gynecology, Vardhman Institute of Medical Sciences, Pawapuri, Nalanda, Bihar, India, for 1 year. Total 220 pregnant female subjects in the age group of 16-55 yrs was selected. Out of them 110 were normotensive pregnant women (NPW) in their third trimester and were chosen as control Group 1 and 110 pregnancy induced hypertensive (PIH) patients in their third trimester were chosen as study Group 2.
Results: The Hcy level was significantly increased with a mean and standard deviation (SD) value of 21.77±4.95µmol/l (p- value=0.001) and the uric acid level was also increased with a mean and SD of 5.15±0.87mg/dl (p-value= 0.003) in the PIH. The Hcy level was 9.22 ± 2.43µmol/land the Uric acid level was 3.27 ± 0.92mg/dl in NPW group. . The magnesium level was lower in the PIH compared to NPW (p - value=0.001)
Conclusion: The Hcy and uric acid levels were increased and Magnesium level was decreased in PIH women than the NPW. So these parameters should be part of the evaluation of the pregnant women presenting with hypertension. Thereby, we can reduce the maternal and fetal mortality rate.
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