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  2. Volume 8, Issue 4
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Online ISSN: 2515-8260

Volume8, Issue4

A Retrospective Evaluation of the Incidence of Acute Ischemic Stroke in Hospitalized Patients with Atrial Fibrillation Who Had Anticoagulation Interruption

    Dr. Rana Randhir Kumar Singh, Dr.Madan Pal Singh, Dr. J.K.L Das

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1396-1402

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Abstract

Aim: To determine theIncidence of Acute Ischemic Stroke in Hospitalized Patients with Atrial Fibrillation Who Had Anticoagulation Interruption.
Methods: A retrospective study was conducted in the Department of Geriatrics- Medicine , Darbhanga Medical College and Hospital, Laheriasarai, Darbhanga, Bihar, India for 1 year. The patients of  60 years and above age group were included in the present study or older who were admitted to the hospital with a primary or secondary diagnosis of AF who had anticoagulation interruption without heparin bridge vs. non-interrupted group.
Results: the mean age was 72.1 ± 11.21 years and 50.89% were female. A total of 50 patients out of 450 (11.11%) had anticoagulation interruption in more than 48 h (median interruption of 67 h). Compared to non-interruption group, patients with anticoagulation interruption were older (mean age 76.45 ± 11.52 vs. 72.06 ± 11.88 years, P = 0.001), had slightly higher CHADS2VASc score (3.98 vs. 3.62, P = 0.01), more likely to have heart failure and less likely to have HTN. Only 10 patients out of 450 (2.22%) had acute ischemic stroke during their hospital stay: 2 patient (4%) in the anticoagulation interruption group, and 8 patients (2%) in the non-interruption group. There was no statistically significant difference in incidence of ischemic stroke between the two groups (1.31% vs. 0.27%, P = 0.27). Short-term interruption of anticoagulation was not associated with a significant increased risk of in-hospital ischemic stroke. CHA2DS2VASc score was an independent strong predictor of in-hospital stroke (odds ratio (OR): 7.77, 95% con- fidence interval (CI): 2.99 - 19.03) In terms of secondary outcomes in anticoagulation interruption versus non-interruption groups, results were as follows: mortality (0 vs. 0.68%, P = 1), bleeding (4% vs. 1%, P = 0.04), number of readmissions within 90 days (48% vs. 37%, P = 0.04) and average LOS (7.74 vs. 2.75 days, P < 0.0001).
Conclusion: The patients with AF the incidence of ischemic stroke during hospitalization is low and did not significantly increase with short-term interruption of anticoagulation. The incidence of ischemic stroke in hospitalized patients with AF is strongly correlated with CHA2DS2VASc score.
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(2021). A Retrospective Evaluation of the Incidence of Acute Ischemic Stroke in Hospitalized Patients with Atrial Fibrillation Who Had Anticoagulation Interruption. European Journal of Molecular & Clinical Medicine, 8(4), 1396-1402.
Dr. Rana Randhir Kumar Singh, Dr.Madan Pal Singh, Dr. J.K.L Das. "A Retrospective Evaluation of the Incidence of Acute Ischemic Stroke in Hospitalized Patients with Atrial Fibrillation Who Had Anticoagulation Interruption". European Journal of Molecular & Clinical Medicine, 8, 4, 2021, 1396-1402.
(2021). 'A Retrospective Evaluation of the Incidence of Acute Ischemic Stroke in Hospitalized Patients with Atrial Fibrillation Who Had Anticoagulation Interruption', European Journal of Molecular & Clinical Medicine, 8(4), pp. 1396-1402.
A Retrospective Evaluation of the Incidence of Acute Ischemic Stroke in Hospitalized Patients with Atrial Fibrillation Who Had Anticoagulation Interruption. European Journal of Molecular & Clinical Medicine, 2021; 8(4): 1396-1402.
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