• Register
  • Login

European Journal of Molecular & Clinical Medicine

  • Home
  • Browse
    • Current Issue
    • By Issue
    • By Subject
    • Keyword Index
    • Author Index
    • Indexing Databases XML
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
Advanced Search

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 8, Issue 3
  3. Author

Online ISSN: 2515-8260

Volume8, Issue3

OXIDATIVE STRESS AND ANTIOXIDANT STATUS OF CERIVASTATIN IN PATIENTS WITH HYPERCHOLESTEROLEMIA

    MD. ABU NASAR KANHAIYA JHA

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 4734-4743

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

Abstract: This study was an attempt to establish the extent of increased oxidative stress in hypercholesterolemic patients and to evaluate the effect of Cerivastatin, a newer statin on the oxidative stress and antioxidant status.There are two types of statins, Lipophilic and Hydrophilic. Lipophilic statins are widely distributed in different tissues, whereas hydrophilic statins are liver specific. Lipophilic statins include atorvastatin, simvastatin, lovastatin, fluvastatin, cerivastatin and pitavastatin, while hydrophilic statins include rosuvastatin and pravastatin. The blood samples of 15 subjects (age and sex matched) each from group I (healthy subjects), group II (hypercholesterolemic patients with cerivastatin treatment) and group III (hypercholesterolemic patients without any hypolipidemic drug) were taken and centrifuged for separation of plasma. Plasma was used for the estimation of vitamin E. The separated cells were washed thrice with 0.9 % w/v cold normal saline and used for the assay of percentage hemolysis of RBCs, malondialdehyde, superoxide dismutase and hemoglobin.Levels of oxidative stress were higher in hypercholesterolemic in comparison to control and cerivastatin group. Levels of antioxidants were higher in cerivastatin group than hypercholesterolemic but were lower than controls. From these findings it was concluded that there is an increase in oxidative stress in hypercholesterolemia but it decreased significantly after 2 months of cerivastatin therapy and antioxidant status also improves in patients taking cerivastatin. 
Keywords:
    Cerivastatin oxidative stress Antioxidant effects Hypercholesterolemic patients
  • PDF (165 K)
  • XML
(2021). OXIDATIVE STRESS AND ANTIOXIDANT STATUS OF CERIVASTATIN IN PATIENTS WITH HYPERCHOLESTEROLEMIA. European Journal of Molecular & Clinical Medicine, 8(3), 4734-4743.
MD. ABU NASAR KANHAIYA JHA. "OXIDATIVE STRESS AND ANTIOXIDANT STATUS OF CERIVASTATIN IN PATIENTS WITH HYPERCHOLESTEROLEMIA". European Journal of Molecular & Clinical Medicine, 8, 3, 2021, 4734-4743.
(2021). 'OXIDATIVE STRESS AND ANTIOXIDANT STATUS OF CERIVASTATIN IN PATIENTS WITH HYPERCHOLESTEROLEMIA', European Journal of Molecular & Clinical Medicine, 8(3), pp. 4734-4743.
OXIDATIVE STRESS AND ANTIOXIDANT STATUS OF CERIVASTATIN IN PATIENTS WITH HYPERCHOLESTEROLEMIA. European Journal of Molecular & Clinical Medicine, 2021; 8(3): 4734-4743.
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 108
  • PDF Download: 122
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
Journal Information

Publisher:

Email:  editor.ejmcm21@gmail.com

  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus