European Journal of Molecular & Clinical Medicine

Abstract

consanguinity supports the homozygosis of recessive susceptibility gene variants and shall be used to investigate a recessive component in inheritance diseases. The knowledge of genetic contribution from maternal and paternal factors for healthy development of pregnancy outcomes is very essential. There is dearth of knowledge regarding the impact of consanguineous marriage on birth weight and placental growth. Hence, present study was conducted to assess the percentiles of birth weight and placental morphometry in consanguineous marriages.
Materials and Method: Study was conducted on 391 subjects in teaching hospital of North Karnataka, India for a period of six months. Ethical clearance was obtained. Data was collected by using standard pretested proforma. Percentiles of birth weight and placental morphometry in consanguineous and non consanguineous groups has been explained in table and box plots have been plotted.
Result: In non-consanguineous group 5^th and 10^th percentiles of birth weight were higher as compared to consanguineous group, after which there was no consistent relationship.
In consanguineous group, percentiles of placental weight were higher as compared to non-consanguineous group except 5^th and 90^th percentiles.
In consanguineous group 25^th to 95^th percentiles of the placental volume were higher as compared to non-consanguineous group whereas, opposite trends were observed in 5^th and 10^thpercentiles.
In consanguineous group the percentiles of placental surface area were higher as compared to non-consanguineous group except in case of 50^th percentile, where both are same (226 cm sq).
Conclusion: In both non-consanguineous and consanguineous group birth weight did not exhibit consistent relation. In consanguineous group, percentiles of placental weight and placental volume were higher as compared to non-consanguineous group, but the relation was not consistent. In consanguineous group the percentiles of placental surface area were higher as compared to non-consanguineous group except in case of 50^th percentile.