Abstract

Background&Method: The study was conducted with aim to evaluate and compare the
efficacy of IV esmolol and IV lignocaine in blunting the hemodynamic response to
laryngoscopy and intubationsat Sanjay Gandhi Medical College, Rewa, M.P. In the operating
room the patients was transferred to the operating table. An intravenous infusion with saline
0.9% was started using 18 G cannula in a peripheral vein. Blood pressure monitored by
manual cuff. A pulse oximeter was placed on the finger. ECG monitoring was also
established. A central venous line placed in the cubital vein using a 375 cava fix and a 0.9%
normal saline was started. Baseline heart rate and blood pressure were recorded. Random
allocation of patients to each group was done lots drawn by a person not taking part in the
study. The investigator that is the person doing the study was unaware of the drug used.
Result: The difference between the groups in distribution of age (p=0.6), weight (p=0.7) and
sex ( p=0.8) were not statistically significant. In duration of laryngoscopy and intubations was
not statistically significant. (P=0.5).In grades of laryngoscope was not statistically significant
(P= 0.51). In experience of anesthetist was not statistically significant. (P=0.37).
Conclusion: Esmolol and lignocaine are both similar in their effectiveness in attenuating the
haemodynamic response to laryngoscopy and intubation’s, but they do not abolish it
completely. More studies need to be carried out to confirm the perception that esmolol in
combination with the newer narcotic agents like fentanyl may abolish the haemodynamic
response to laryngoscopy and intubations, particularly required in the patients in whom a
single hyper dynamic response may be catastrophic.