European Journal of Molecular & Clinical Medicine

Abstract

Aim: To evaluate the role of early Vs delayed laparoscopic cholecystectomy in mild and
moderate acute gallstone pancreatitis
Methods:This randomized prospective study conducted in the Department ofSurgery after
taking the approval of the protocol review committee and institutional ethics committee. 100
patients were included in the study. They were divided into two groups with 50 patients in
each group. Patients with mild and moderate acute gallstone pancreatitis were included in this
study.
Results: The age distribution in both the groups was comparable with no statistically
significant difference observed. The mean age in Group A was 42.9±9.24 years and in Group
B was 43.025±9.56 years (p=0.857). Out of 100 cases 21 were males and 79 were females.
There was no statistically significant difference in the sex distribution between the two
groups. There was no statistically significant difference between the two groups with p-value
=0.079 and 0.707 for amylase and lipase respectively. Modified CECT severity index was
used to assess severity of acute pancreatitis. Group A had a mean score of 3.2±1.20 and
Group B had mean score of 3.3±1.28 p-value=0.757 and there was no statistically significant
difference between two groups. 16% in Group A and 22% in Group B underwent preoperative
ERCP and the difference was statistically not significant. There was no recurrence
of pancreatitis in group A, however 16% cases of group B had recurrent pancreatitis and
the results were statically significant which are tabulated as under.There was no
recurrence of cholecystitis in group A, however 16% cases of group B had recurrent
cholecystitis and the results were statistically significant which are tabulated as under.
Conclusion: We conclude that, early laparoscopic cholecystectomy in the index admission in
mild and moderate gallstone induced pancreatitis is a feasible and a safe modality for the
treatment of acute mild and moderate gallstone pancreatitis and early cholecystectomy
decreases the incidence of recurrent episodes of pancreatitis and cholecystitis in patients with
gallstones.