European Journal of Molecular & Clinical Medicine

Abstract

Background: Vernal keratoconjunctivitis (VKC) is a chronic recurrent non-infectious
allergic disease that generally affects children and young adults. The present study was
conducted to assess efficacy of topical 0.05% cyclosporine in
Vernalkeratoconjunctivitis.
Materials & Methods: 86 patients diagnosed with Vernalkeratoconjunctivitis (VKC) of
both genderswere enrolled. All were prescribed topical 0.05% cyclosporine 4 times a
day. Patients underwent complete ophthalmic examination and symptoms and signs and
intraocular pressure using rebound tonometer. The patients were evaluated at weeks 4,
8 and 12 after the initiation of therapy. Symptoms and signs before and after treatment,
during the four-week intervals, were recorded and scores between 0 and 3 were
assigned.
Results: Out of 86 patients, males were 56 and females were 30. Median of symptoms
score at baseline was 11, at 4 weeks was 4, at 8 weeks was 5 and at 12 weeks was 4. Sign
score at baseline was 6, at 4 weeks was 4, at 8 weeks was 3 and at 12 weeks was 3. The
difference was significant (P< 0.05).
Conclusion: Topical cyclosporine 0.05% help to reduce corticosteroid usage, is an
effective and safe alternative for the treatment of resistant VKC.