European Journal of Molecular & Clinical Medicine

Abstract

Aim: the aim of the study to analyse the thyroid profile, hs-CRP and lipid profile in newly detected hypothyroid adults in comparison to controls and also to compare the above parameters in subclinical and clinical hypothyroid cases.
Methods: The study was a cross sectional study which was carried in the Department of Cardiology, PMCH, Patna, Bihar, India for 1 year. Total 200 patients were divided into 2 groups. Group-1 for newly detected hypothyroid adults and Group 2 as Controls. Blood samples were collected with full aseptic precautions after obtaining informed consent. Clot activator that contains vacuum evacuated tubes for analysis of serum TSH, FT3, FT4, TC, HDL-c, LDL-c, TG, hs-CRP. Then after collection, serum samples were stored at -20⁰ until analyzed. Anthropometric measurements for BMI, height (cm) and body weight (kg) were measured.
 Results: In the study, the mean TSH levels (15.27 ± 9.2µIU/ml) of cases were high compared to controls (3.1 ± 0.88µIU/ml) and were statistically significant (p<0.001). The mean serum hs-CRP levels in both the study groups was within the reference range, but it was high and statistically significant in cases than in control (p = 0.003). The total cholesterol level in cases (182.29 ± 39.75mg/dl) and control (184.27±28.37mg/dl) were within the reference range and there was no statistical significance (p = 0.81). Further it was found that HDL-c in cases (45.89±9.47mg/dl) and control (52.87±6.7mg/dl) were found to be lower in cases compared to controls and the difference was statistically significant (p < 0.001). The mean LDLc value in cases (145.14±34.12mg/dl) and control (132.05±32.14mg/dl) was high in cases and the difference was statistically significant (p= 0.01). The triglyceride levels of cases (159.26±49.87mg/dl) were significantly higher than that of control (146.23±29.27mg/dl) and was statistically significant (p=0.02). hs -CRP levels were in within reference range for 77 (77%) of cases and 91(91%)controls whereas above the normal range was seen in 23(23%) cases and only 9(9%) controls. Out of 100, 64% (n=64) were subclinical hypothyroid (SCH) and 36% (n=36) were clinical hypothyroid (CH) cases. There was a significant increase in serum TSH in CH (24.11 ± 9.1µIU/ml) as compared to SCH (10.2 ± 2.2 µIU/ml). The difference was statistically significant (p<0.001). hs-CRP levels though high in CH than SCH were statistically insignificant (p=0.58).
Conclusion: we concluded that the hypertriglyceridemia and at risk hs-CRP levels though seen in hypothyroid cases were more prominent in CH cases than SCH.