European Journal of Molecular & Clinical Medicine

Abstract

Urethral stricture disease has always been a challenge for urologists. Different treatment
modalities that are used for treatment of urethral stricture disease are dilatation, urethrotomy,
stent placement. Internal urethrotomy is a safe first line treatment for urethral strictures
independent of etiology and location, with an overall primary success rate of 60-70%.Visual
internal urethrotomy was done in usual manner using cold knife. Injection is prepared by
diluting triamcinolone 40mg, mitomycin 2mg in 5-10mL of saline according to length of
stricture and was injected intralesional at the site of urethrotomy using William’s endoscopic
needle. At every site 1-2mL was injected. After confirming free passage of cystoscope into
the bladder, an 16 or 18 Fr foley’s catheter was left in place for 2-3 days.In our study total of
7 patients lost follow up and among remaining 37 patients total of 10 patients had recurrence,
8 patients in group A had recurrence at end of 6 months, 1 patients at 3 months after
procedure and 7 patients at 6 months after procedure where as in group B only 2 patients had
recurrence 1 at 3 months and 1 at 6 months post procedure, both groups were statistically
comparable with respect to age stricture length,site and etiology.From our study we can
conclude that, Injection of both triamcinolone, mitomycin C at stricture site after VIU can be
considered as safe and effective adjuvant modality compared to VIU alone for short term
management of stricture urethra.