European Journal of Molecular & Clinical Medicine

Abstract

Pregabalin is a structural analogue of gamma aminobutyric acid, substituted at the 3-position;
this facilitates diffusion across the blood-brain barrier. Efficacy of pregabalin has been
proven in neuropathic pain, incisional injury, inflammatory injury. Its mechanism of action is
probably the same as gabapentin but it is more lipid soluble and has superior pharmacokinetic
profile. Due to its sleep modulating effects, it has been used as an anxiolytic. Pregabalin
increases stages III-IV sleep phases and also decreases awakening at night. Patients were
counselled regarding the tablet used in preemptive analgesia its advantages and
disadvantages, the purpose of its use, they were also explained regarding the follow up till
24hr and spinal anaesthesia procedure to be used in the study and consent was taken for the
same. Ramsey sedation score of all the patients was score = 2. None of patients complained
of dizziness in group A. Ramsey sedation score of all the patients was score = 2.2.85% (1
patient) complained of dizziness in group B.