European Journal of Molecular & Clinical Medicine

Abstract

Background: In India, cardiovascular disease (CVD) is the main cause of morbidity and
mortality. According to recent trends, this group of disorders has expanded to younger
age groups as well. Cardiovascular illnesses are on the rise in India, affecting both men
and women in both urban and rural areas. The objective of this study was to analyse
serum uric acid levels correlate these values with Killip class in patients of acute MI.
Materials and Methods: Study was prospective type conducted at Dr. Baba
SahebAmbedkar Medical College and Hospital, Rohini, New Delhi from September
2016 to August 2017. A total of 100 patients of acute MI admitted to the ICCU, falling
into inclusion criteria were enrolled. Information was collected through a pre tested
and structured proforma for each patient. Also, physical examination and laboratory
investigation with special reference to Killip classification of heart failure was carried
out. During data analysis, a p value of <0.05 was considered statistically significant.
Results: Mean age of population 54.77 years. This study population had male
predominance (69.0%). In our study out of 100 patients 85 (85%) patients were STEMI
and 15 (15%) patients were NSTEMI. Mean uric acid on day 7 in patients with Killip
class I was 4.72 mg/dl and subjects with Killip class II was 6.62 mg/dl. In multivariate
logistics regression no factors were significantly affecting mortality after adjusting for
confounding factors.
Conclusion: From our study, we conclude that serum uric acid levels are correlated
with Killip class and patients with higher Killip class have higher serum uric acid levels
in acute myocardial infraction.