European Journal of Molecular & Clinical Medicine

Abstract

Background: Bone morphogenetic proteins (BMP) are multi-functionalgrowth factors that
belong to the transforming growth factor beta (TGF-beta) superfamily. The purpose of the
study is to determine difference between radiological and functional outcome in TLIF surgery
with use of BMP 2 vs without BMP 2 in adult patients.
Methods: The present study evaluated data obtained between May 2016 and July 2017 on
patients in whom BMP-2 was used in conjunction with TLIF. 150 fulfilled the study criteria
whose mean age was 54.6 years [range 25–65 years]). Twenty-five patients (33.8%) had
previously undergone lumbar surgeries (discectomy, fusion, and decompression).
Result: Both groups had similar gender distribution and average age at surgery (48.9 ±
12.2years for the BMP group and 44.6 ± 13.7 years for the non-BMP group, p>0.05). As
expected, the BMP group had a shorter median follow-up time of 5.05 ± 7.10 years while the
non-BMP group was followed for a median of years 5.06 ± 12.6.
Conclusion: It is important that clinicians explain these findings to patients so that they can
make informed choices about the type of surgery they would prefer. The use of BMP safe and
effective in the context of TLIF procedures, and thoughtful discussion with patients about the
pros and cons of BMP utilization during surgery is recommended