European Journal of Molecular & Clinical Medicine

Abstract

Propranolol hydrochloride is used to treat high blood pressure, thyrotoxicosis, capillary
hemangiomas, performance anxiety, and essential tremors and used to prevent migraine
headaches. In this investigation-controlled release tablet of Propranolol Hcl was prepared
using different polymers such as xanthan gum, tragacanth, sodium carboxy-methylcellulose,
HPMC K4M, Eudragit S100, ethyl cellulose by direct compression method. All the precompression
and post compression parameters of designed formulations of F1-F8 were
evaluated and found to be within permissible limits. The optimized formulation (F7) showed
a maximum percentage of drug release (100%) within 6hrs when compared to other
formulations. From the FT-IR study it was concluded that there were no possible drug and
polymer interactions. The short-term stability studies were carried out at 40±2°C and 75±5%
RH and confirmed no changes in the weight, hardness and friability. Based on study results
it may be concluded that tablets prepared will emerge as eminent candidates in treatment of
hypertension.