European Journal of Molecular & Clinical Medicine

Abstract

Introduction: Establishing or ruling out the diagnosis of carcinoma of prostate has been
a challenging task for pathologists for many years .it was an observational study where
patients who underwent TURP procedure were studied. The present study is an attempt
to understand the histopathological spectrum of prostatic lesions and study the
demographic distribution of various prostatic lesions.
Methods: The present study includes 125 cases of prostate specimen from January 2018
to September 2021 received in the post graduate department of Pathology, Tripura
Medical College. H and E stained sections were examined. The relevant clinical details
pertaining to age, clinical complaints and microscopic details are analyzed and
compared with other similar studies.
Result: Total 125 case were studied among which 69 (55.2%) cases were found to be
consistent with BPH and 24 cases were found to be malignant lesion (19.2%). 24 cases
were found to be BPH with associated prostatitis like features, consistent with benign
prostatic lesion. High grade Prostatic Intraepithelial lesions were seen in 8 cases (6.4%).
Out of the 24 malignant cases, majority had Gleason score between 8-10. Perineural
invasion was seen in 10 out of 24 malignant cases (41.6%). All malignant lesions were
adenocarcinoma and 20 were incidental carcinoma which accounted for 16% of all
prostatic lesions. Serum prostate specific antigen levels were available in 24 cases of
prostatic adenocarcinoma cases. 21 out of 24 cases had serum prostate specific antigen
levels greater than 10 ng/ml. (87.5%). Grade Group 4 had the maximum number of
cases i.e 45.8%. Out of 125 cases, 89 (71.2%) cases were from urban areas and 36
(28.8%) cases were from rural areas. All the 24 cases with prostatic adenocarcinoma
were from urban areas.