European Journal of Molecular & Clinical Medicine

Abstract

Background: Infantile Haemangioma (IH)has long been considered as an angiogenic disease because of the tangled disorganized mass of blood vessels
in the tumor. This study aimed to prove the safety and efficacy of medical treatment prior to surgical intervention in management of haemangioma.
Patients and methods: This study was involved patients with infantile haemangioma disfiguring or complaining who admitted to  Zagazig University Hospitals. All patients presented to vascular surgery department were subjected to medical treatment with beta blockers and followed up every 2 months for 6 months for possibility of surgical intervention.
Results: The current study included patients with infantile haemangioma disfiguring or complaining, their mean age was 2.95±1.57. Male patients represent 54.2% and female represent 45.8% of studied group. The majority of outcome were excellent (29.2%), very good (8.3%), good (37.5%) and bad (16.7%). Bleeding reported at 4 cases with 16.7% ulceration and infection 8.3%.  Medical management was in 66.7% and surgical in 33.3% and combined were in 29.2%.  There was significant decrease at all time from pre to 6 month.   The association between basic demographic and hemangiomas characters and type of management were significantly associated with surgical. Surgical management significantly associated with bleeding, and associated with ulceration and infection but not significantly.
Conclusion: Propranolol may be more effective and safer in treatment of infantile hemangiomas (IH) and may also be used as a first-line therapy than previously established therapies, and may be an alternative when more widely accepted treatments for IH have failed. Surgical procedures can keep back for complicated IH in which conservative medical therapy is ineffective or contraindicated.