Abstract

Background:Psoriasis is a chronic immune-mediated skin disease that affects 125
million people worldwide, which is 2 to 3 percent of total population. Psoriasis is a
common, chronic, inflammatory disease that is associated with an increased risk of
cardiovascular, metabolic, and renal disease in a manner that varies with psoriasis
severity and is often independent of traditional risk factors.
Aim: To study the association of HbA1C and uric acid with psoriasisin the Kashmiri
population.
Method: A total of 70 cases, diagnosed for psoriasis were undertaken during the study
period December 2018 to February 2021 from the department of Dermatology in the
test group. An equal number of age and sex matched healthy individuals with no skin
disease were taken as control group. Blood samples were collected and analysed in the
laboratory of department of Biochemistry, Government Medical College, and Srinagar.
All study participants provided written informed consent prior to enrolment.
Results:Psoriatic patients had higher levels of HbA1c (5.3 ± 0.09 vs 4.9 ± 0.063 mg/dl;
P=0.005) and significantly greater prevalence of hyperglycemia (24.2% vs 12.8%;
P=0.009) than individuals without psoriasis. Prevalence of pre diabetes and diabetes in
patients with psoriasis was 11.1 % and 14.2 % respectively as compared to
controls.Multivariate logistic regression analysis showed that psoriasis can be a strong
predictor of hyperglycemia (odds ratio 2.14; 95% confidence interval 0.939-4.903;
P=0.001). Patients with psoriasis also had significantly higher levels of serum uric acid
than controls. Mean serum uric acid in cases was 6.13 ± 0.187 and in controls it was 5.56
± 0.123 with p value<0.05.
Conclusion: There was a significant increase in Hba1c levels in patients with psoriasis
than control. In addition, we found increased level of serum uric acid in patients with
psoriasis than control. There was a positive correlation between HbA1c values and
higher BMI.