European Journal of Molecular & Clinical Medicine

Abstract

Introduction-uric acid production is a normal phenomenon in normotensive pregnancy, however in preeclampsia and eclampsia uric acid production exaggerated may result in greater potential for endothelial oxidative damage. It has been reported that higher UA is indicative in women with preeclampsia and eclampsia.
Material and method-Prospective study was done for duration of 16 months i.e. may 2019 to Sep.2020 in the department of Biochemistry of central research laboratory of Magadh Medical College, Gaya, India. A total no.100 women in which 50 cases (30 Preeclampsia & 20 Eclampsia) and 50 control (30 were normal pregnant & 20 normal non- pregnant women with reproductive age group)
Result-The mean serum UA , 24hours urinary protein  were higher in preeclampsia and eclampsia compared to control.
Conclusion-A significantly increased serum UA in preeclampsia and eclampsia than control group indicate the significant role in pathogenesis of PIH. Total serum Protein levels are reduced in preeclampsia and eclampsia compared to control.