European Journal of Molecular & Clinical Medicine

Abstract

Background: Liver is one of the important target organ for insulin and its counter regulatory hormones, such as glucagon. Chronic liver disease (CLD) is often associated with glucose intolerance and diabetes. Glucose intolerance and frank diabetes are seen in a lot number of patients with chronic liver disease. The number of CLD patients continues to increase in INDIA because of alcohol (ethanol) consumption and epidemics of obesity and non-alcoholic fatty liver diseases (NAFLD).
Methods: This is a observational, study (descriptive study) of 60 patients admitted in the wards of, Department of General Medicine, Jawaharlal Nehru Medical College and Hospital, Bhagalpur. Study  period of June  2020 to  Sep 2021 who matched the inclusion criteria. Data was collected after obtaining informed/written consent from patient. Detailed  history, clinical examination, general physical and systemic examination and relevant laboratory investigations were done.
Conclusion: The occurrence of glucose metabolism disorder in chronic liver disease was high. OGTT helped in unmasking diabetes in many patients. The number of impaired glucose tolerance and diabetics were more in Child Pugh B and C compared to Child Pugh A.