European Journal of Molecular & Clinical Medicine

Abstract

Background:Asthma is characterized by chronic inflammation of upper and lower
airways. Allergic diseases like allergic asthma, allergic rhinitis is increasing worldwide.
C-reactive protein is a marker of inflammation and infection. A positive relationship of
inflammation has been shown between raised CRP levels in allergic asthma.
Aims and Objective: The study aims to evaluate high sensitivity CRP levels in allergic
asthma cases and in controls.
Materials and Methods:The study was carried out in the Department of Biochemistry at
Index Medical College Hospital and Research Centre, Indore Madhya Pradesh. The
study was done on 80 males and females subjects of the age group 6 to 18 years. Forty
males and female children suffering from allergic asthma attending the Ear, Nose and
Throat outpatient department of IMCHRC, Indore were taken as the case. Forty
healthy males and female children were taken as controls after careful selection as per
inclusion and exclusion criteria. CRP was done by latex enhanced
tubidometericimmunoassay (CRP kit).
Results:The levels of CRP were significantly higher in allergic asthma cases (P<0.001)as
compared to controls (0.001).
Conclusion:The results of the present study indicate that the concentration of CRP was
increased in asthma cases as compared to the controls.In allergic asthma there
isincreased inflammation of upper and lower airways and so the levels of CRP are
increased.