European Journal of Molecular & Clinical Medicine

Abstract

Objectives:1)To study level of serum highdensity lipoprotein (HDL) level in subclinical
hypothyroidism andeuthyroid patients 2) To study association between serum HDL and
serum TSH in subclinical hypothyroidism.
Materials and Methods:The study was hospital based observational study which
included15 patients of subclinical hypothyroidism and 15 patient’s euthyroid after
diagnosis based on theirserum thyroid stimulating hormone (TSH), freeT3 and freeT4
level done during their regular visit to outpatient medicine department.Bloodsample
was collected of all the participants after an overnight (12hours) fasting and serum high
density lipoprotein levels was estimated. Statisticalanalysis was done on collected data.
Results: Participants with euthyroidism and subclinical hypothyroidism showed no
significant difference in serum high density lipoprotein levels and a negative correlation
was found between serum TSH and serum HDL level in subclinical hypothyroidism
group.
Conclusions:Thyroid hormones have various effects on lipid metabolism.The
effects of subclinical hypothyroidism on serum HDL level were not statistically
significantand a negative correlation between serum TSH and serum HDL which was
suggestive of linear decrease in serum HDL with increase in serum TSH levels.