European Journal of Molecular & Clinical Medicine

Abstract

Background
Cardiorenal syndrome (CRS) is not a newly discovered syndrome. The adverse outcomes of
the renal impairment in patients with Heart failure were known since long. Our aim in this
study was to evaluate the occurrence of AKI, to determine the outcome (morbidity and
mortality) in patients suffering with AKI.
Methods
The present observational prospective study was conducted for a duration of 1 yearamong
100 patients (age 18 years or more) admitted to hospital with acute decompensated heart
failure.A written informed consent taken from each patient and were then screened for
cardiac dysfunction by a detailed history, clinical examination and
echocardiography.Univariate logistic regression was used to find out association of various
outcomes with AKI. A p value of <0.05 was considered statistically significant.
Results
The mean age of the study population was 58.98 ± 17.16 years. The mean Boston criteria for
the population was 9.87 ± 1.36. Baseline S. creatinine, eGFR and even B. Urea were strongly
associated with the occurrence of AKI. Presence of diastolic dysfunction was associated with
AKI. Mortality and readmission were significantly higher in AKI group as compared to non-
AKI group.The predictive value of AKI was maximum with the baseline S. creatinine.
Conclusion
Cardio-renal syndrome is a commonly seen in patients admitted in hospital. AKI can lead to
poor cardiac output or pre-renal failure as a result of overuse of diuretics. The mechanism
involved is complex. AKI in patients admitted with ADHF has poor prognosis with increased
mortality and longer duration of hospital stay.