European Journal of Molecular & Clinical Medicine

Abstract

A 67-year-old man with neurofibromatosis type 1 presented with multiple nodular
swelling all over the body and a swelling arising from posterior aspect of right thigh
suggestive of neurofibroma arising from the sciatic nerve with malignant potential. The
chief complaint of patient was severe excruciating pain into the whole left lower limb.
The differential diagnosis of malignant peripheral nerve sheath tumor,
neurofibrosarcoma was based on clinical, radiological, and histological evidence. The
tumor apparently originated in sciatic nerve at the posterior aspect of the right thigh.
The tumor mass was excised completely without neural damage to the sciatic nerve.
Patient is relieved of pain and totally asymptomatic after 2 year follow up.