European Journal of Molecular & Clinical Medicine

Abstract

Objective: Left Ventricular diastolic dysfunction (LVDD) is an asymptomatic disease
linked to eventual heart failure. Obesity and overweight are not known to be
independently linked to LVDD. The objective is to adjudicate whether increased body
size has an independent influence on LVDD.
Study design and sample: For this study, a total of 495 subjects were selected. LV
diastolic function was estimated using both traditional and tissue-Doppler imaging.
Peak early and late trans-mitral diastolic flow velocities (E, A) and early diastolic mitral
annulus velocity (E′) were utilized to calculate E/A and E/E′. The individuals were
categorised into three groups: overweight (BMI 25.0–29.9), normal weight (BMI 25.0),
and obesity (BMI 30).
Results: BMI was independently linked with greater E, A, and E/E′, an indication of LV
filling pressure, in multivariate models (all p<0.01). Overweight and obese participants
demonstrated lower E′ (both p<0.01) and greater E/E′ (both p<0.01) than respondents
with normal weight. Obese participants had a lower E/A than normal weight
respondents (p<0.01). When contrasted with normal weight people, the perils of
diastolic dysfunction were considerably greater among overweight and obese people.
Conclusion: Irrespective of LV mass or other risk variables, having an elevated BMI
was connected to poor LV diastolic performance. Both overweight and obese patients
have higher chances of LVDD, which may explain some of the heart failure associated
risks with both conditions