A Clinico pathological Study of Cystic Lung Lesions in Children and Prognostic Evaluation with Ki – 67 at Tertiary Care Hospital
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 659-663
AbstractIntroduction: Congenital cystic lesions of the lung are uncommon but share similar
embryologic and clinical characteristics. An overall incidence of congenital cystic lesions
of the lung is 1/10,000 to 1/25,000 births (and 2.2% as compared to acquired lesions).
Presentation varies from life-threatening symptoms at birth to incidental findings at
autopsy. Diagnosis is either made in utero or due to complications of the lesion, such as
lung abscess, pneumonia, or pneumothorax.
Materials and Methods: This is a prospective study conducted in the Department of
Pathology at Ayaan Insitute of Medical Sciences, Kankamidi from January 2020 to
December 2021. The present study was done to evaluate the demographic profile,
clinical, radiological and histopathological findings of cystic lung lesions in children and
to demonstrate efficacy of Ki 67 as a prognostic marker in predicting malignancy in
these lesions. A total of 53 lobectomy specimens received and studied in the present
Results: Out of these 53 cases were lobectomy specimens of cystic lung lesions. Highest
number of cystic lung lesions were observed in the left upper lobe. (23 cases) and the
lowest number of cystic lung lesions were observed in the right upper lobe (3cases).
Highest number of cystic lung lesions were Congenital lobar emphysema (52.83 %) and
least number of cystic lung lesions were Bronchogenic cyst (5.66 %). Among all cystic
lung lesions maximum cyst had size range between 0.5 to 2 cm. Immunohistochemical
staining using Ki 67 showed a high proliferative index in 5 cases of CCAM. Remaining
all 7 cases of CCAM and 2 cases each of Bronchogenic cyst, Intra lobar Sequestration
and Congenital lobar emphysema had low proliferative index.
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