Clinicopathological and Immunohistochemical Profile of Malignant Surface Epithelial Ovarian Tumors
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 946-952
AbstractBackground: The ovaries are important organs for reproduction. The ovaries are
paired pelvic organs located on the sides of the uterus close to the lateral pelvic wall,
behind the broad ligament and anterior to the rectum. Generally ovarian tumors occur
in perimenopausal and post-menopausal women, infrequently in children also. The risk
of developing an ovarian malignancy peak in fifth decade of life. Aim and Objectives:
To Study and characterize the ovarian tumors based on gross and histopathological
features. To compare the frequency of benign and malignant neoplasms of the ovary
with other studies.
Materials and Methods: This study is a prospective study. The cases were obtained
from Department of Pathology, at a tertiary care hospital in Alappuzha over a period of
1 year. The gross specimen received were fixed in 10 % formalin for 24hours and from
every specimen multiple sections were taken from representative site for histological
examination. The number of blocks varied from four to eight in number. Sections were
processed in paraffin, which were cut at five microns thickness. Sections were stained
with conventional hematoxylin and eosin stain. The lesions were classified and studied
as per the WHO classification of ovarian tumors (2014).
Results: A total of 80 SEOT ovarian tumors were studied. Of these ovarian tumors, 42
were benign, 11 were borderline and 27 were malignant. Right sided tumors of ovary 48
(60%) were more common than the left sided tumors 25(31%). 07(09%) cases were
bilateral. The commonest epithelial tumors were serous 64 cases (75 %), 16 mucinous
(25%), remaining are not presented on my study period. Serous tumors formed the
majority of ovarian neoplasms in the study. There was a total of 64 serous tumors,
constituting about 75%.
Conclusion: The findings of this study indicate that IHC marker report of ER, PR
status and Ki-67 If included in each pathology report will pave the way for better
Understanding of Biological behavior and modify treatment strategies.
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