• Register
  • Login

European Journal of Molecular & Clinical Medicine

  • Home
  • Browse
    • Current Issue
    • By Issue
    • By Subject
    • Keyword Index
    • Author Index
    • Indexing Databases XML
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
Advanced Search

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 9, Issue 3
  3. Author

Online ISSN: 2515-8260

Volume9, Issue3

Serum Insulin and Atherosclerotic Markers in Acanthosis Nigricans Patients

    Shravya B, Navaneetha Reddy Pisati, Vijay Bhasker Reddy Ch, Chinnapu Reddy Gopu, Ashok Rao Matety

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 968-975

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

Background: To study serum insulin levels and atherosclerotic markers in patients with
acanthosis nigricans in a rural tertiary care center.
Materials and Methods: It was a Cross sectional study. The study was conducted in the
Departments of Biochemistry and Dermatology, Venereology, Leprosy (DVL), at
Kamineni Institute of Medical Sciences, India.
Results: Total number of patients recruited for the study was 50. Mean age of the
patient was 26.8 years. Females (60%) have outnumbered males (40%). Overall
majority of the acanthosis nigricans patients were students (46%). Among females
majority of them were housewives (22%). In a majority of the patients, neck was the
initial site of darkening (82%). Most of them have duration of darkening of skin for
more than one year (64%) and 84% of the patients had an insidious onset. Forty six
percent of patients had associated medical illness such as hypothyroidism (22%),
diabetes mellitus (10%), hypertension (8%), polycystic ovarian syndrome (4%),
psoriasis (2%). Neck(98%) is the most common site of acanthosis nigricans followed by
axilla(88%); elbow(42%); periorbital region(36%); groin(34%); knees(24%);
temples(22%); infralabial region(20%); antecubital fossa(14%); perioral and perinasal
(12% each); knuckles(10%); skin over hyoid bone(8%); sides of waist and
inframammary areas(6% each) and popliteal fossa(2%). Out of 50 patients, raised
serum insulin levels seen in 54% patients, of which 42% are non-diabetics and 12% are
diabetics. Also, 96% had normal fasting blood sugars (FBS <110mg/dL), 80% had
normal postprandial blood sugars (PPBS <140mg/dL). All patients (100%) had normal
total cholesterol (< 250mg/dL), 80% patients had normal HDLc (>35mg/dL), 98% had
normal LDLc (< 130mg/dL), 80% had normal triglycerides (<160mg/dL), 86% had
normal VLDLc < 40mg/dL, out of the total 50 patients with acanthosis nigricans.
Conclusion: Hypothyroidism was present in 22% of the patients with acanthosis
nigricans whereas diabetes mellitus was present in 10% of the patients with acanthosis
nigricans. Levels of fasting serum insulin were raised in 54% of patients having burke’s
neck severity score of 2, 3, 4 and neck texture score of 2,3 and axilla severity score of 2,3
in patients with acanthosis nigricans. About 20% of studied patients had decreased
HDL cholesterol levels(<35 mg/dL and increased serum triglycerides(>160 mg/dL).
Keywords:
    acanthosis nigricans Fasting Insulin Axilla Triglycerides Neck severity Popliteal fossa Hypothyroidism
  • PDF (247 K)
  • XML
(2022). Serum Insulin and Atherosclerotic Markers in Acanthosis Nigricans Patients. European Journal of Molecular & Clinical Medicine, 9(3), 968-975.
Shravya B, Navaneetha Reddy Pisati, Vijay Bhasker Reddy Ch, Chinnapu Reddy Gopu, Ashok Rao Matety. "Serum Insulin and Atherosclerotic Markers in Acanthosis Nigricans Patients". European Journal of Molecular & Clinical Medicine, 9, 3, 2022, 968-975.
(2022). 'Serum Insulin and Atherosclerotic Markers in Acanthosis Nigricans Patients', European Journal of Molecular & Clinical Medicine, 9(3), pp. 968-975.
Serum Insulin and Atherosclerotic Markers in Acanthosis Nigricans Patients. European Journal of Molecular & Clinical Medicine, 2022; 9(3): 968-975.
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 89
  • PDF Download: 139
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
Journal Information

Publisher:

Email:  editor.ejmcm21@gmail.com

  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus