European Journal of Molecular & Clinical Medicine

Abstract

Background:Breast cancer continues to be a significant health threat, being the second
most common cancer among Indian women. The present study was conducted to assess
total PSA and free PSA levels in female patients with breast cancer.
Materials & Methods: female patients with tumours growth of breast were included.
Patients were classified into benign and malignant growth according to WHO
classification. Patients were classified into group I (breast growth) and healthy subjects
were put in group II. Parameters such as serum total prostate specific antigen (TPSA),
serum free prostate specific antigen (FPSA) was recorded.
Results: Age group 20-40 years had 30 in group I and 28 in group II and 40-60 years
had 35 in group I and 37 in group II. There were 38 benign and 27 malignant lesions of
breast. The difference was significant (P< 0.05). The mean total PSA in benign lesions
was 12.2, in malignant was 15.7 and in group II was 1.8 and free PSA was 0.15 in
benign, 0.22 in malignant and 2 in group II. The difference was significant (P< 0.05).
Conclusion: Both benign and malignant breast tumour patients exhibited high level of
free and total prostate specific antigen.