European Journal of Molecular & Clinical Medicine

Abstract

Electrophysiological studies revealed that Esmolol causes an increase in sinus cycle length
and sinus node recovery time. Electrocardiographic parameters like 'PR' 'QRS' and 'QT'
intervals were not prolonged. In contrast to other beta blockers, electrophysiological values
return to baseline values within a period of 30 minutes after withdrawing the drug. When
infused at a dose of 200 micrograms/kg/minute, Esmolol can significantly reduce the namely,
resting heart rate, Systolic blood pressure, rate pressure product, cardiac index. Esmolol can
also attenuate isoprenaline induced tachycardia. After obtaining clearance from the
Institutional Ethical Committee and informed written consent, a prospective randomized
double-blinded study was conducted on sixty patients scheduled for various elective surgical
procedures belonging to patients physical status American Society of Anesthesiologists
(ASA) Classes I and II were included in the study. In esmolol group the basal heart rate was
97.8bpm. During reversal heart rate increased to 102.7bpm. During drug injection and
subsequently heart rate decreased as shown in table. At 15min post extubation heart rate was
84.6bpm which was less than basal.
In labetalol group the basal heart rate was 97.5bpm. During reversal heart rate increased to
103.1bpm. During drug injection and subsequently heart rate decreased as shown in table. At
15min post extubation heart rate was 69.9bpm which was much less than basal.