Abstract

Complications after trachea extubation are three times more common than complications occurring
during tracheal intubation and induction of anaesthesia. Hypertension and tachycardia are well
documented events during extubation. These hemodynamic responses reflects sympatho-adrenal reflex
stimulation (epipharyngeal and laryngo pharyngeal stimulation) with concomitant increase in plasma
level of catecholamines and activation of alpha and beta adrenergic receptors. A routine preanesthetic
examination was conducted assessing the general condition of the patients on the evening before
surgery. From all patients, informed consent was obtained. All patients were kept nil per oral for 8 h.
On arrival in the operating room, i.v. line was established, and fluid dextrose with normal saline was
started. Patients were connected to multichannel monitor which records HR, noninvasive blood
pressure, end-tidal carbon dioxide, and oxygen saturation. Statistical evaluation between the group
showed there was no significance of SBP between the group at basal, extubation upto 1th minute post
extubation (p>0.05). At 2th min (p=0.034), 3rd min (p-0.023) and 15th min (p=0.024) post extubation
there was significance esmolol> labetalol at 2nd and 3rd, labetalol >esmolol at 15th min.