• Register
  • Login

European Journal of Molecular & Clinical Medicine

  • Home
  • Browse
    • Current Issue
    • By Issue
    • By Subject
    • Keyword Index
    • Author Index
    • Indexing Databases XML
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
Advanced Search

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 9, Issue 3
  3. Author

Online ISSN: 2515-8260

Volume9, Issue3

Antibacterial effect of Swertia chirata against multi-drug resistant strains S. aureus and E. coli: in vivo and in vitro study

    Bindu Sati, Sanjay Bhatt .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1106-1115

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

Misuse and overuse of antibiotics results in widespread multi-drug resistance. The major cause of increased mortality and morbidity rates is Multi-drug resistance to antibiotics and it becomes a global heath challenges now a days, therefore it becomes a necessity and need for researchers to seek for alternative and natural sources of antimicrobials. In the present study an experimental trial (In-vitro and In-vivo) was undertaken to examine the antibacterial activity of extracts of Swertia chirata leaf against multi drug resistant (MDR) E.coli and S.aureus. Broth dilution test for MIC and Disc diffusion method for antimicrobial susceptibility test were applied to investigate Antibacterial activity of plant methanolic extracts. Twenty five albino mice weighted between 180-200g were used for bacterial inhibitory activity (In- Vivo). Plant extract showed broad spectrum of antibacterial activity against S.aureus in comparison to E.coli and showed MIC values of 20µg/ml. Swertia chirata plant extract contains lesser inhibition zone against E. coli (8.7±0.80) and showed highest zone of inhibition against S.aureus (16.2±0.60). It can be concluded that Swertia chirata plant extract was significantly better (P<0.05) against S.aureus than E. coli. The number of bacteria in treated groups was very low, These findings have cleared demonstrated that the clearance of bacteria from the blood of infected mice by sub-MIC of plant extract was significant. the findings of present study provide a suitable evidences for the use of a drug composed of plant extract as a new generation of drugs to attack the antibiotic resistance of bacteria.
Keywords:
    antibacterial activity Taxus baccata Swertia chirata Escherichia coli staphylococcus aureus
  • PDF (262 K)
  • XML
(2022). Antibacterial effect of Swertia chirata against multi-drug resistant strains S. aureus and E. coli: in vivo and in vitro study. European Journal of Molecular & Clinical Medicine, 9(3), 1106-1115.
Bindu Sati, Sanjay Bhatt .. "Antibacterial effect of Swertia chirata against multi-drug resistant strains S. aureus and E. coli: in vivo and in vitro study". European Journal of Molecular & Clinical Medicine, 9, 3, 2022, 1106-1115.
(2022). 'Antibacterial effect of Swertia chirata against multi-drug resistant strains S. aureus and E. coli: in vivo and in vitro study', European Journal of Molecular & Clinical Medicine, 9(3), pp. 1106-1115.
Antibacterial effect of Swertia chirata against multi-drug resistant strains S. aureus and E. coli: in vivo and in vitro study. European Journal of Molecular & Clinical Medicine, 2022; 9(3): 1106-1115.
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 90
  • PDF Download: 196
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
Journal Information

Publisher:

Email:  editor.ejmcm21@gmail.com

  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus