European Journal of Molecular & Clinical Medicine

Abstract

Background: Standard assessment of renal function in pregnancy is by measurement of
serum creatinine concentration yet normal gestational ranges have not been established.
The aim of this systematic review was to define the difference in serum creatinine in a
healthy pregnancy compared with concentrations in non-pregnant women to facilitate
identification of abnormal kidney function in pregnancy.
Materials and Methods: The study was performed on 70 pregnant women. Out of which
35 women were pregnancy induced hypertensive and 35 were normal pregnant women.
Results: The result showed significantly high blood pressure (SBP-197.21±21.7 VS
187.28±8.69, DBP 124.36±9.41 VS 99.2±6.28) and Blood urea (42.31 ±7.81 mg% VS
41.30±9.29 mg%), serum creatinine (3.45 ±1.19 mg% VS 3.18±1.38 mg%), serum uric
acid level (9.89±3.16 mg% VS 7.34±0.9 mg%) in pregnancy induced hypertensive
women compares to normal pregnant women. In the present study, in pre-eclampsia,
there is elevation of serum uric acid and serum creatinine elevated values are
statistically significant.
Conclusion: There is a renal derangement of parameters in preeclampsia so it may be
advised to renal function test to confirm involvement of renal dysfunctions.
Measurement of renal function Test could be used as a biochemical indicator in
pregnancy induced hypertensive women.