European Journal of Molecular & Clinical Medicine

Abstract

Background: Bilirubin is a metabolic byproduct of the breakdown of hemoglobin degradation which itself must be metabolized for appropriate excretion. High levels of bilirubin are associated with decreased risk of coronary heart disease (CHD) and cardiovascular disease (CVD).
Objectives: To study the level is to see correlation between serum bilirubin level and Risk factor of cardiac disease in patients admitted in hospital.
Methodology:  This study includes 100 Male Indian subjects between 35 to 60 years of age who visited medicine OPD of our institute. Biochemical test like Lipid profile, Serum bilirubin and blood sugar(Fasting & Post Prandial) were measured on a fully automatedanalyzer along with quality control sera. Obtained Results were analyzed statistically to calculate p value and to see the difference of significance.
Results: HDL level between OPDand IPD (31.92 ± 4.25 mg/dl and 49.92 ± 7.23 mg/dl ) subjects respectively. In the same manner this table also showed a higher level of FBS 122.23±4.2 mg/dl and PP2BS 132.23±8.0 mg/dl in OPD subjects as compared to IPD patients but the difference among them was not significant. It was represented that the OPD subjects were more prone to risk of CVD because the level of S.choletserol was 220.92 ± 40.21 as compared to 209.45 ± 29.90 in IPD subjects.(p value:<0.001 significant)Regarding serum Triglyceride level , there is no such significant difference found among two group. While comparing the level of serum LDL it was 164.64±15.29 and 134.83±10.39 in Control and case Group Respectively.(p <0.001). The Level of Total bilirubin was 0.84±0.41 mg/dl in control group and 4.42±3.1 in case Group and difference among them was highly significant.
Conclusions: From my study it will be conclude that there is a significant negative relationship was demonstrated between baseline bilirubin levels and incident CHD and CVD death and the level of serum bilirubin is important parameter for defining risk of cardiovascular disease.