European Journal of Molecular & Clinical Medicine

Abstract

Background:Gastroduodenal diseases are perhaps the commonest diseases in adult
population worldwide. The present study was conducted to assess histopathological spectrum
of various gastroduodenal lesions.
Materials & Methods:72 patients with upper GI symptoms referred for endoscopy of both
genders were included. Gastric mucosal biopsies from body and antrum were also taken for
detection of H. pylori. The biopsy specimens were put into a small labelled bottle containing
10% buffered formalin. The biopsies were then processed, cut into sections of 4 micrometer
thickness and stained with Haematoxylin and Eosin (H&E) and modified Giemsa techniques.
Results: Age group (years) 11-20 had 5, 21-30 had 11, 31-40 had 34 and 41-50 had 22
patients. The difference was significant (P< 0.05). Gastroduodenal lesions chronic gastritis in
32, benign gastric ulcer + chronic gastritis in11, duodenitis + chronic gastritis in 5,
benign duodenal ulcer + chronic gastritis in 10, MAL Toma in 8 and gastric carcinoma in 6
cases. The difference was significant (P< 0.05). H. pylori positivity in gastroduodenal lesions
was seen in chronic gastritis in 20, benign gastric ulcer + chronic gastritis in 5, duodenitis +
chronic gastritis in 2, benign duodenal ulcer + chronic gastritis in 6, MAL Toma in 4 and
gastric carcinoma in 5 cases. The difference was significant (P< 0.05).
Conclusion: Chronic gastritis was the most commonly diagnosed gastroduodenal lesion
followed by duodenitis, duodenal ulcer and gastric carcinoma.