European Journal of Molecular & Clinical Medicine

Abstract

Background:Periampullary tumours are one of the most common cause of cancer
related deaths. They have least survival rates. As most of the periampullary tumours
are malignat tumours, early diagnosis and management improves the survival.
Ampullary adenocarcinomas shows distinct morphologies with specific
immunohistochemistry profile.
Materials and Methods: This study was done over a period of three years in the
department of pathology. Rsectedspecimens (Whipple’s procedure and excision
biopsies) received in the department were adequately grossed, sectioned and stained
with H&E. CK20 and MUC 1 immunohistochemistry markers were applied for
ampullary adenocarcinomas.
Results: Out of 26 cases, 15 were of ampullary adenocarcinomas. Out of ampullary
adenocarcinomas, eight were intestinal type, five were pancreaticobiliary type and two
were mixed type. On IHC with CK20 and MUC1,four cases came out to be intestinal
type adenocarcinomas. Follow up was done in some of these cases to assess the survival
rates.
Conclusion: Prognosis varies among tumour subtypes. Histological subclassification still
holds good for assessing the prognosis in periampullary tumours