European Journal of Molecular & Clinical Medicine

Abstract

Background: Red cell distribution width (RDW) to platelet ratio (RPR) is a
prognosticator in acute pancreatitis and myocardial infarction; however, the prognostic
values of RDW and RPR in breast cancer have not been studied. This retrospective
analysis of 50 breast cancer patients investigated the association between RDW and
RPR and clinicopathological characteristics and prognosis, compared to platelet
distribution width to platelet count ratio (PDW/P) which is a known independent
prognostic factor in patients with breast cancer. Aims and Objective: Our study aimed
to know significance of elevated RPR in breast cancer, to correlate the RPR with the
clinicopathological characteristics of breast cancer (tumor grade, lymphatic spread,
over expression of hormonal receptors and HER2 protein).
Materials &Methods:It was a Retrospective study. Patients with histologically
confirmed breast cancer were included in study. Patients with heart failure / On
dialysis/ Lacking the entire set of clinicopathological data were excluded in this study.
Results: RPR was higher in patients with breast cancer. RPR elevation was significantly
correlated with high grade tumors, number of infiltrated lymph nodes and HER2 over
expression.
Conclusion: Our study indicates that elevated preoperative RDW levels are indicative of
tumor spread and progression of breast cancer. RPR is a cost-effective and novel
biomarker which can help in assessing the microscopic grading of Breast cancer.