Clinical Profile of Immune Thrombocytopenic Purpura in Paediatric age Group
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 1966-1976
AbstractBackground: Platelets play a vital role in hemostasis. Idiopathic / Immune
thrombocytopenic purpura (ITP) is a common bleeding disorder in children, where
autoantibodies mediated consumption of the platelets, suppression of platelet
production by bone marrow megakaryocytes leads to thrombocytopenia and bleeding
manifestations. Incidence is 6.4 per 10000 among children and 3.3 per 10000 adults per
year.1 There is highest male to female ratio in infancy and it decreases with older age
groupchildren. No significant seasonal variation. Vaccination may play an important
role in the etiology of ITP in infants. History of a preceding viral infection 1-6 weeks
before the onset disease is present in 60% of cases. Bone. narrow was routinely
performed but evidences confirmedthat its rarely needed at presentation, must be
considered if having severe bleeding or not responding to treatment.
Materials &Methods:Details about children with ITP who presented to our hospital
between October 2020 and August 2021 were collected using a proforma. The study was
designed as a cross-sectional study. To meet the sample size, convenience sampling was
Results: Total number of children recruited with a clinical diagnosis of primary itp was
120 after excluding the ones which had a secondary cause identified, the total primary
itp studied were 100. among them based on the duration of symptoms (as per
definitions) they were categorized into newly diagnosed, persistent and chronic itp.
There were 46 cases of chronic itp and 44 cases of persistent ITP. 73 percent of all
patients were between the ages of 1 and 10 years. in total, 8.9 percent of them had severe
bleeds. there was no link discovered between bleeding and platelet count. a high nordic
score (10-14) had a high predictability for short-term symptoms.
Conclusion: In our study, there was a higher incidence of its presenting in the hospital.
Higher a percentage of them had severe bleeding.
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