The study of biochemical (CPK-MB) ,ECG, and Echocardiographic changes in patients of snake bite
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 2055-2064
AbstractBackground:Snake bite is an occupational hazard for farmers and farm laborers in the Indian
subcontinent. Every year approximately 15,000 people reportedly died due to snake venom
interaction in India alone. However, unreported deaths are estimated to be many times greater
than the reported cases in the subcontinent.
Materials & Methods:ThisCross Sectional Observational Study was carried on sample size of
75 patients of snake bite admitted in Ward/ICU, Department Of Medicine, NSCB Medical
College, and Jabalpur on patients of snake bite reporting from all over mahakaushal area of
central India from March 2017 to August 2018.
Results: CPK-MB analysis shown to have highest raised values in neurotoxic group that is
32.3±0.9 IU/L which was higher in cases where local signs were prominent, 34.0±1.1 IU/L and
in cases without local signs it was lower 30.7±1.6 IU/L. CPK-MB values were for vasculotoxic
bites was also raised 27.3±1.2 IU/L, while for non-poisonous snake bites it was below upper
limit, 21±2.1 IU/L. A total of 39.2% (n=33) patients shown to have positive ECG findings while
rest 60.7% (n=51) shown no abnormality in electrocardiogram. Analysis of 2D-ECHO findings
was done for pattern of positive findings and found that most common positive finding was
pericardial effusion with 9 (10.71%) patients followed by 6 (7.1%) patients showed diastolic
dysfunction, and 5 (5.9%) patients each shown to have systolic dysfunction and RWMA.
Conclusion: CPK-MBanalysis shown to have highest raised values in neurotoxic group which
was higher in cases where local signs were prominent, and in cases without local signs it was
lower. Abnormal ECG was significant predictor of mortality in vasculotoxic snake bites.
Echocardiography was a significant predictor of mortality in neurotoxic bites.
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