European Journal of Molecular & Clinical Medicine

Abstract

Background: The induction of anesthesia, laryngoscopy, tracheal intubation and surgical
stimulation often evoke cardiovascular responses characterized by alteration in systemic
arterial blood pressure, heart rate and cardiac rhythm
Aim: Efficacy of low dose of clonidine in attenuating the haemodynamic response to
intubation. Comparing two doses of oral clonidine in attenuating haemodynamic response to
intubation.
Materials and Methods: The study will be conducted on 60 patients who will be undergoing
elective surgery under general anesthesia during the period of 2017 to 2019.
Group CL-1 and Group CL-2 patients were premeditated with oral Clonidine 60 minutes
prior to the surgery.
Randomisation: All the patients included in the study were randomized into 3 groups,
Group CL-1: Patients who received oral Clonidine premedication at the dose of 1 microgram
per kg.
Group CL-2: Patients who received clonidine premedication at the dose of 2microgram per
kg.
Group CS: Patients who received premedication with oral saline.
After shifting the patient inside the operating room noninvasive blood pressure, saturation
probe and electrocardiogram monitoring with 5 leads were attached and baseline values were
recorded.
Duration of laryngoscopy and intubation (from the time laryngoscope inserted till the end
tidal CO2 is seen on the monitor) was noted, grade of laryngoscopy, heart rate, systolic
diastolic and mean blood pressures are noted at the time of induction, just before
laryngoscopy, immediately after intubation and 1,3 and 5mins after intubation by investigator
2.
Results: In the present study when we evaluated the heart rate,SBP,DBP,MAP. There was
least variation HR, SBP, DBP and MAP, in those who received 2 mg clonidine as those who
received 1 mg clonidine as compared to the placebo saline group