European Journal of Molecular & Clinical Medicine

Abstract

Background and objectives : Testosterone has been shown to provide a protective role in the development of cardiovascular diseases in men, the low serum level of testosterone in the middle age patients  may contribute to coronary artery disease (CAD),this study was applied to check serum levels of  testosterone in less than 50 age group patients with CAD and it`s relation to other risk factors.
Subjects and Methods: This cross sectional coparative study was applied over 6 months from first of April 2018 to first of October 2018 ,this study was conducted in coronary care unit of al_hussein teaching hospital and  outpatient on 101 middle age males ,fifty five of them presented with ACS and the other 46 apparently normal(as healthy control) ,mean age was 43.5±5.6 years ,serum testosterone was tested for both groups in addition to data that collected from them by a performed questionnaire, a man with a total testosterone level below 300 ng/dL should be diagnosed with low testosterone.
Result: serum testosterone level was low in 37 of 55 patient group (92.5%) and 3 of 46 of control group (7.5%) with a significant p.value (0.05) , 94% of patient group presented within 40_50 years age group and73% for control group.
 Low testosterone significantly associated with age >40 years()and other risk factor of CAD including obesity and dyslipidemia.
Conclusion: Serum testosterone  level were found to be decreased significantly in patients with ACS and this low level significantly associated with other risk factor for ACS.