A Study of Aerobic Bacteriological Profile and Antimicrobial Susceptibility Pattern of Isolates in Patients with Chronic Osteomyelitis at Tertiary Care Hospital
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 2210-2217
Abstract
Introduction: In recent times, there has been change in bacteriological profile of chronic osteomyelitis cases as well as susceptibility of antibiotics.Objectives: 1. To study Demographic characteristics of Chronic Osteomyelitis cases, 2. To isolate causative Aerobic bacteria (other than Mycobacteria) 3. To analyze Antimicrobial Susceptibility Pattern of isolated aerobic bacteria.
Methodology: A cross sectional hospital-based study of 1 year duration was conducted at Department of Microbiology, S. P. Medical College, Bikaner, Rajasthan. After obtaining informed verbal consent, 110 chronic osteomyelitis cases were recruited to study following nonprobability consecutive sampling. Their pus samples were taken and studied for staining, presence of enzymes, biochemical reactions, fermentation tests, antibiotic susceptibility testing. Obtained results were analysed and presented through tables and diagrams.
Results: 50% cases had S. aureus and 18% had P. aeruginosa in their pus samples. Majority of patients were male and almost 1/3rd cases belonged to 16-30 years age group. S. aureus isolates were sensitive to Cotrimoxazole & Linezolid. Most of the isolate of Klebsiella pneumoniae (83.33%) were sensitive to Meropenem. All isolates of Pseudomonas aeruginosa (100%) were sensitive to Polymyxin B and Colistin C.
Conclusion: Study of bacteriological profile and antimicrobial susceptibility pattern helps significantly in clinical management decisions.
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