A Hospital Based Prospective Study to Compare the Effect of Intravenously Administered Clonidine and Magnesium Sulfate on Hemodynamic Responses During Laparoscopic Surgeries at a Tertiary Care Center
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 2232-2239
Abstract
Background: Nowadays laparoscopic surgery is going to be the first choice for surgical management of various indications, especially with the well-trained laparoscopic surgeon. The benefits of minimal access techniques include less pain, early mobilization, shorter hospital stay, and better cosmetic results, which have further increased its applications. The aim of this study to compare the efficacy of intravenously administered clonidine and magnesium sulfate on hemodynamic stress response during laparoscopic surgeries.Materials& Methods: This is a prospective randomized study done on 50 ASA physical status I and II subjects in the age group of 20-60 years planned for elective laparoscopic surgeries with CO2 pneumoperitoneum were enrolled in department of anesthesia at American International Institute of Medical Sciences, Udaipur, Rajasthan, India during one year period. They were randomly allocated to one of the two study groups, Group C (Clonidine group) and Group M (Magnesium group).Group CPatients were given a solution containing clonidine 1.5 μg/kg (group C) in 50 ml of normal saline over a period of 15 min and Group MPatients were given a solution containing magnesium sulfate 50 mg/kg in 50 ml of normal saline over a period of 15 min. The parameters like Systolic blood pressure, Diastolic blood pressure, mean arterial Blood pressure, heart rate and SPO2 were recorded.
Results: The mean value of age was 39.25 years in group C and 42.78 years in group M, which was statistical not significant (P>0.05). The comparison of mean value of body weight and duration of surgery was statistical not significant (P>0.05). Hemodynamic changes such as Systolic blood pressure, Diastolic blood pressure, mean arterial Blood pressure, heart rate and SPO2 was statistical nonsignificant in different time interval. Statistically significant difference observed in the Modified Ram say sedation scale between the two groups. Clonidine found to have significantly lesser sedation than magnesium at the time of extubation.
Conclusion: We concluded that intravenous administration of clonidine 1.5μg/kg before pneumoperitoneum is as effective as intravenous magnesium sulfate 50mg/kg before pneumoperitoneum in blunting the haemodynamic stress responses during laparoscopic surgeries and clonidine has lesser sedation than magnesium at extubation.
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