European Journal of Molecular & Clinical Medicine

Abstract

BACKGROUND
            Clinically significant hematologic abnormalities are common in HIV infection. Early identification of the hematologic abnormalities would lead to appropriate planning of treatment strategies and prevent further complication. This study was conducted in order to know the pattern of these hematologic abnormalities and its correlation with CD4 count among HIV patients of Vindhya region who were on ART.
METHODOLOGY
            This was a cross sectional, analytic study conducted in the Department of Medicine, SSMCRewa, M.P. between January 2020 to June 2021. The study group included a total number of 200 patients with HIV infection on ART. Patients were investigated for Hb%, total count, differential count and platelet count. CD4 count was obtained by flow cytometric analysis.
AIMS AND OBJECTIVES:
To analyse the hematological profile of people living with HIV/AIDS and To identify the possible correlation between CD4 count and hematological abnormalities.
RESULTS
            Among 200 patients,52.0%were males and 48.0% were females.90.5% were from rural area.The maximum no. of cases had heterosexual mode of transmission, i.e. 179 (89.5%).Out of 145 anemic cases, maximum no. i.e. 68 (46.89%) cases had normocytic anemia followed by 42 (28.97%) cases of macrocytic anemia.Among patients who had ≤200 CD4 counts, 21.27% cases had severe anemia whereas among patients who had >500 CD4 counts none had severe anemia.11.0%ofpatients hadthrombocytopenia. Among patients who have ≤200 CD4 counts, 23.40% have thrombocytopenia whereas among patients who had>500 CD4 counts only 4.87% had thrombocytopenia.   
CONCLUSIONS
            Hematologic manifestations of HIV infection are common and frequent with progression of disease.
            The Present Study revealed a significant increase in the number and severity of cases of anemia with decreasing CD4 cell count.
            We have to provide proper awareness and education about the HIV safety measures, especially in young adolescents and adults, emphasizing to rural population.
            It is important to simultaneously treat HIV patients for hematologic manifestations to reduce morbidity.