Haemodynamics of 2-chloroprocaine and bupivacaine for lower limb surgeries under spinal anaesthesia
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 2, Pages 1162-1167
AbstractThe lipophilic portion is essential for anaesthetic activity and therapeutically useful local anaesthetics require a delicate balance between lipid solubility and water solubility. Addition of a butyl group to the Piperidine nitrogen of Mepivacaine results in bupivacaine, which is 35 times more lipid soluble and has a potency and duration of action three to four times that of Mepivacaine. Inclusion criteria were American Society of Anaesthesiologists (ASA) physical status I or II, either sex, age 18-60 years, presenting for lower limb surgeries. Exclusion criteria were patient allergic to drug, heart block/dysrhythmia. Hundred slips were made in such a manner that fifty slips had Group 1 written on it and the other fifty had Group 2. In the present study it was observed that there was no statistically significant difference in distribution of patients based on ASA grade in between the two groups p >0.05. In the present study it was observed that there was there no statistically significant difference in adverse events in between group.
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