European Journal of Molecular & Clinical Medicine

Abstract

Background:Breast cancer is common cancer in women in both the developed and the less
developed nations. Since the 2008 estimates, breast cancer incidence has increased by more than
20%, while mortality has increased by 14%. Breast cancer is now the most common cancer in
most cities in India, and second most common in the rural areas.AIM:To evaluate the percentage
of breast carcinomas expressing estrogen receptors and progesterone receptors and to correlate the
ER & PR status with other prognostic parameters like histological type, grade, tumour size, and
lymph node metastasis.Material & Methods: Study Design: Hospital based Prospective
observational study.Study area: Dept. of. Pathology, in a tertiary care teaching college and
hospital. Study Period: 1 year.Study population: patients who were resected for surgical breast
specimens by modified radical mastectomy, lumpectomy or specimens and sent for pathological
analysis. Sample size: study consisted a total of 100 patients. Sampling method: Simple
Random sampling method.Inclusion Criteria: Carcinomatous lesions of breast. Ethical
consideration: Institutional Ethical committee permission was taken prior to the commencement
of the study.Study tools and Data collection procedure: The specimens were thoroughly
grossed according to the standard protocol and those which fulfilled the inclusion criteria were
evaluated for following data (1) tumour size (2) infiltration of the tumour to nipple and areola (3)
infiltration onto posterior margin (4) necrosis (5) desmoplasia (6) calcifications and (7) number
of lymph nodes involved.Statistical Analysis:The data was collected, compiled and compared
statistically by frequency distribution and percentage proportion. Quantitative data variables
were expressed by using Descriptive statistics (Mean ± SD). Qualitative data variables were
expressed by using frequency and Percentage (%).Student t test (two tailed, independent) has
been used to find the significance of study parameters on continuous scale between two groups
Inter group analysis) on metric parameters. Chi-square test has been used.